Characterization and reversal of Doxorubicin-mediated biphasic activation of ERK and persistent excitability in sensory neurons of Aplysia californica

Doxorubicin (DOX), a common chemotherapeutic agent, impairs synaptic plasticity. DOX also causes a persistent increase in basal neuronal excitability, which occludes serotonin-induced enhanced excitability. Therefore, we sought to characterize and reverse DOX-induced physiological changes and modula...

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Detalles Bibliográficos
Autores principales: Lakshminarasimhan, Harini, Coughlin, Brittany L., Darr, Amber S., Byrne, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495788/
https://www.ncbi.nlm.nih.gov/pubmed/28674403
http://dx.doi.org/10.1038/s41598-017-04634-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495788/
https://www.ncbi.nlm.nih.gov/pubmed/28674403
http://dx.doi.org/10.1038/s41598-017-04634-4

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