Chronic stress and intestinal barrier dysfunction: Glucocorticoid receptor and transcription repressor HES1 regulate tight junction protein Claudin-1 promoter

Chronic stress and elevated glucocorticoid hormone are associated with decreases in the intestinal epithelial tight junction protein claudin-1 (CLDN1). Human/rat CLDN1 promoters contain glucocorticoid response elements (GREs) and adjacent transcription repressor HES1 binding N-boxes. Notch signaling...

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Detalles Bibliográficos
Autores principales: Zheng, Gen, Victor Fon, Gordon, Meixner, Walter, Creekmore, Amy, Zong, Ye, K. Dame, Michael, Colacino, Justin, Dedhia, Priya H., Hong, Shuangsong, Wiley, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495803/
https://www.ncbi.nlm.nih.gov/pubmed/28674421
http://dx.doi.org/10.1038/s41598-017-04755-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495803/
https://www.ncbi.nlm.nih.gov/pubmed/28674421
http://dx.doi.org/10.1038/s41598-017-04755-w

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