Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice

Cd39 scavenges extracellular ATP and ADP, ultimately generating adenosine, a nucleoside, which has anti-inflammatory effects in the vasculature. We have evaluated the role of Cd39 in the development of atherosclerosis in hyperlipidemic mice. ApoE KO (Cd39(+/+)/ApoE(−/−)) and Cd39/ApoE double KO (DKO...

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Detalles Bibliográficos
Autores principales: De Giorgi, Marco, Enjyoji, Keiichi, Jiang, Gordon, Csizmadia, Eva, Mitsuhashi, Shuji, Gumina, Richard J., Smolenski, Ryszard T., Robson, Simon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496028/
https://www.ncbi.nlm.nih.gov/pubmed/28487312
http://dx.doi.org/10.1194/jlr.M072132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496028/
https://www.ncbi.nlm.nih.gov/pubmed/28487312
http://dx.doi.org/10.1194/jlr.M072132

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