Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma

Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity also in patient cells resistant to bortezomib...

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Detalles Bibliográficos
Autores principales: Muz, Barbara, Azab, Feda, de la Puente, Pilar, Landesman, Yosef, Azab, Abdel Kareem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496204/
https://www.ncbi.nlm.nih.gov/pubmed/28668761
http://dx.doi.org/10.1016/j.tranon.2017.04.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496204/
https://www.ncbi.nlm.nih.gov/pubmed/28668761
http://dx.doi.org/10.1016/j.tranon.2017.04.010

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