Cargando…
TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1
Endothelial cell adhesion and migration are critical steps of the angiogenic process, whose dysfunction is associated with tumor growth and metastasis. The TRPM8 channel has recently been proposed to play a protective role in prostate cancer by impairing cell motility. However, the mechanisms by whi...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496606/ https://www.ncbi.nlm.nih.gov/pubmed/28550110 http://dx.doi.org/10.1083/jcb.201506024 |