TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1

Endothelial cell adhesion and migration are critical steps of the angiogenic process, whose dysfunction is associated with tumor growth and metastasis. The TRPM8 channel has recently been proposed to play a protective role in prostate cancer by impairing cell motility. However, the mechanisms by whi...

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Detalles Bibliográficos
Autores principales: Genova, Tullio, Grolez, Guillaume P., Camillo, Chiara, Bernardini, Michela, Bokhobza, Alexandre, Richard, Elodie, Scianna, Marco, Lemonnier, Loic, Valdembri, Donatella, Munaron, Luca, Philips, Mark R., Mattot, Virginie, Serini, Guido, Prevarskaya, Natalia, Gkika, Dimitra, Pla, Alessandra Fiorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496606/
https://www.ncbi.nlm.nih.gov/pubmed/28550110
http://dx.doi.org/10.1083/jcb.201506024

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