A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials

BACKGROUND: Composite endpoints comprising hospital admissions and death are the primary outcome in many cardiovascular clinical trials. For statistical analysis, a Cox proportional hazards model for the time to first event is commonly applied. There is an ongoing debate on whether multiple episodes...

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Detalles Bibliográficos
Autores principales: Jahn-Eimermacher, Antje, Ingel, Katharina, Preussler, Stella, Bayes-Genis, Antoni, Binder, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496642/
https://www.ncbi.nlm.nih.gov/pubmed/28676086
http://dx.doi.org/10.1186/s12874-017-0366-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496642/
https://www.ncbi.nlm.nih.gov/pubmed/28676086
http://dx.doi.org/10.1186/s12874-017-0366-9

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