Repeat application of microneedles does not alter skin appearance or barrier function and causes no measurable disturbance of serum biomarkers of infection, inflammation or immunity in mice in vivo

We address, for the first time, the impact of skin insertion on multiple occasions of polymeric microneedle arrays in an animal model in vivo. Dissolving microneedle arrays prepared from aqueous blends of 20% w/w Gantrez® S-97 BF and 40% w/w poly(vinyl pyrrolidone) 58 kDa and hydrogel-forming micron...

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Detalles Bibliográficos
Autores principales: Vicente-Perez, Eva M., Larrañeta, Eneko, McCrudden, Maelíosa T.C., Kissenpfennig, Adrien, Hegarty, Shauna, McCarthy, Helen O., Donnelly, Ryan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496649/
https://www.ncbi.nlm.nih.gov/pubmed/28478160
http://dx.doi.org/10.1016/j.ejpb.2017.04.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496649/
https://www.ncbi.nlm.nih.gov/pubmed/28478160
http://dx.doi.org/10.1016/j.ejpb.2017.04.029

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