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Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood

High temperature requirement factor A3 (HtrA3), a member of the HtrA protease family, is highly expressed in the developing placenta, including the maternal decidual cells in both mice and humans. In this study we deleted the HtrA3 gene in the mouse and crossed females carrying zero, one, or two Htr...

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Detalles Bibliográficos
Autores principales: Li, Ying, Salamonsen, Lois A., Hyett, Jonathan, Costa, Fabricio da Silva, Nie, Guiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496872/
https://www.ncbi.nlm.nih.gov/pubmed/28676687
http://dx.doi.org/10.1038/s41598-017-04867-3