Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction

JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full activation of JAK2 are unclear. Here, we report a positive role for ubiquitination of JAK2 during GM-CSF-induced activation. Upon GM-CSF stimulation, JAK2 ubiq...

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Detalles Bibliográficos
Autores principales: Liu, Chun-Shan, Yang-Yen, Hsin-Fang, Suen, Ching-Shu, Hwang, Ming-Jing, Yen, Jeffrey Jong-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496907/
https://www.ncbi.nlm.nih.gov/pubmed/28676638
http://dx.doi.org/10.1038/s41598-017-04078-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496907/
https://www.ncbi.nlm.nih.gov/pubmed/28676638
http://dx.doi.org/10.1038/s41598-017-04078-w

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