Prolyl Hydroxylase Domain-2 Inhibition Improves Skeletal Muscle Regeneration in a Male Murine Model of Obesity

Obesity leads to a loss of muscle mass and impaired muscle regeneration. In obese individuals, pathologically elevated levels of prolyl hydroxylase domain enzyme 2 (PHD2) limit skeletal muscle hypoxia-inducible factor-1 alpha and vascular endothelial growth factor (VEGF) expression. Loss of local VE...

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Detalles Bibliográficos
Autores principales: Sinha, Indranil, Sakthivel, Dharaniya, Olenchock, Benjamin A., Kruse, Carla R., Williams, Jeremy, Varon, David E., Smith, Jessica D., Madenci, Arin L., Nuutila, Kristo, Wagers, Amy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497248/
https://www.ncbi.nlm.nih.gov/pubmed/28725215
http://dx.doi.org/10.3389/fendo.2017.00153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497248/
https://www.ncbi.nlm.nih.gov/pubmed/28725215
http://dx.doi.org/10.3389/fendo.2017.00153

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