Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I

Peroxiredoxin I (Prx I) plays an important role in cancer development and inflammation. It is a dual-functional protein which acts as both an antioxidant enzyme and a molecular chaperone. While there have been intensive studies on its peroxidase activity, Prx I's chaperone activity remains elus...

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Detalles Bibliográficos
Autores principales: Zhao, Qian, Ding, Yu, Deng, Zhangshuang, Lee, On-Yi, Gao, Peng, Chen, Pin, Rose, Rebecca J., Zhao, Hong, Zhang, Zhehao, Tao, Xin-Pei, Heck, Albert J. R., Kao, Richard, Yang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497274/
https://www.ncbi.nlm.nih.gov/pubmed/28717468
http://dx.doi.org/10.1039/c5sc00633c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497274/
https://www.ncbi.nlm.nih.gov/pubmed/28717468
http://dx.doi.org/10.1039/c5sc00633c

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