Aberrant intracellular metabolism of T‐DM1 confers T‐DM1 resistance in human epidermal growth factor receptor 2‐positive gastric cancer cells

Trastuzumab emtansine (T‐DM1), an antibody–drug conjugate (ADC) consisting of human epidermal growth factor receptor 2 (HER2)‐targeted mAb trastuzumab linked to antimicrotubule agent mertansine (DM1), has been approved for the treatment of HER2‐positive metastatic breast cancer. Acquired resistance...

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Detalles Bibliográficos
Autores principales: Wang, Hongbin, Wang, Wenqian, Xu, Yongping, Yang, Yong, Chen, Xiaoyan, Quan, Haitian, Lou, Liguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497802/
https://www.ncbi.nlm.nih.gov/pubmed/28388007
http://dx.doi.org/10.1111/cas.13253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497802/
https://www.ncbi.nlm.nih.gov/pubmed/28388007
http://dx.doi.org/10.1111/cas.13253

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