Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects. NKTR-214 is a clinical-stage biologic that comprises interleukin-2 (IL2) protein bound by multiple releasable polyethylene glycol (PEG) chain...

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Detalles Bibliográficos
Autores principales: Charych, Deborah, Khalili, Samira, Dixit, Vidula, Kirk, Peter, Chang, Thomas, Langowski, John, Rubas, Werner, Doberstein, Stephen K., Eldon, Michael, Hoch, Ute, Zalevsky, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497954/
https://www.ncbi.nlm.nih.gov/pubmed/28678791
http://dx.doi.org/10.1371/journal.pone.0179431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497954/
https://www.ncbi.nlm.nih.gov/pubmed/28678791
http://dx.doi.org/10.1371/journal.pone.0179431

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