Activation of Dun1 in response to nuclear DNA instability accounts for the increase in mitochondrial point mutations in Rad27/FEN1 deficient S. cerevisiae

Rad27/FEN1 nuclease that plays important roles in the maintenance of DNA stability in the nucleus has recently been shown to reside in mitochondria. Accordingly, it has been established that Rad27 deficiency causes increased mutagenesis, but decreased microsatellite instability and homologous recomb...

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Detalles Bibliográficos
Autores principales: Kaniak-Golik, Aneta, Kuberska, Renata, Dzierzbicki, Piotr, Sledziewska-Gojska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497989/
https://www.ncbi.nlm.nih.gov/pubmed/28678842
http://dx.doi.org/10.1371/journal.pone.0180153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497989/
https://www.ncbi.nlm.nih.gov/pubmed/28678842
http://dx.doi.org/10.1371/journal.pone.0180153

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