Splenocyte Infusion and Whole-Body Irradiation for Induction of Peripheral Tolerance in Porcine Lung Transplantation: Modifications of the Preconditioning Regime for Improved Clinical Feasibility

BACKGROUND: Preoperative low-dose whole-body irradiation (IRR) with 1.5 and 7 Gy thymic IRR of the recipient, combined with a perioperative donor splenocyte infusion lead to reliable donor specific peripheral tolerance in our allogeneic porcine lung transplantation model. To reduce the toxicity of t...

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Detalles Bibliográficos
Autores principales: Jansson, Katharina, Dreckmann, Karla, Sommer, Wiebke, Avsar, Murat, Salman, Jawad, Siemeni, Thierry, Knöfel, Ann-Kathrin, Pauksch, Linda, Gottlieb, Jens, Frühauf, Jörg, Werner, Martin, Jonigk, Danny, Strüber, Martin, Haverich, Axel, Warnecke, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Tolerance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498011/
https://www.ncbi.nlm.nih.gov/pubmed/28706973
http://dx.doi.org/10.1097/TXD.0000000000000689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498011/
https://www.ncbi.nlm.nih.gov/pubmed/28706973
http://dx.doi.org/10.1097/TXD.0000000000000689

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