Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia

Kif5A is a neuronally-enriched isoform of the Kinesin-1 family of cellular transport motors. 23 separate mutations in the motor domain of Kif5A have been identified in patients with the complicated form of hereditary spastic paraplegia (HSP). We performed in vitro assays on dimeric recombinant Kif5A...

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Detalles Bibliográficos
Autores principales: Jennings, Scott, Chenevert, Madeline, Liu, Liqiong, Mottamal, Madhusoodanan, Wojcik, Edward J., Huckaba, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498027/
https://www.ncbi.nlm.nih.gov/pubmed/28678816
http://dx.doi.org/10.1371/journal.pone.0180353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498027/
https://www.ncbi.nlm.nih.gov/pubmed/28678816
http://dx.doi.org/10.1371/journal.pone.0180353

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