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Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia
Kif5A is a neuronally-enriched isoform of the Kinesin-1 family of cellular transport motors. 23 separate mutations in the motor domain of Kif5A have been identified in patients with the complicated form of hereditary spastic paraplegia (HSP). We performed in vitro assays on dimeric recombinant Kif5A...
Autores principales: | Jennings, Scott, Chenevert, Madeline, Liu, Liqiong, Mottamal, Madhusoodanan, Wojcik, Edward J., Huckaba, Thomas M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498027/ https://www.ncbi.nlm.nih.gov/pubmed/28678816 http://dx.doi.org/10.1371/journal.pone.0180353 |
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