Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA

Two mechanisms dominate the clinical pipeline for oligonucleotide-based gene silencing, namely, the antisense approach that recruits RNase H to cleave target RNA and the RNAi approach that recruits the RISC complex to cleave target RNA. Multiple chemical designs can be used to elicit each pathway. W...

Descripción completa

Detalles Bibliográficos
Autores principales: Pendergraff, Hannah M., Krishnamurthy, Pranathi Meda, Debacker, Alexandre J., Moazami, Michael P., Sharma, Vivek K., Niitsoo, Liisa, Yu, Yong, Tan, Yen Nee, Haitchi, Hans Michael, Watts, Jonathan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498289/
https://www.ncbi.nlm.nih.gov/pubmed/28918018
http://dx.doi.org/10.1016/j.omtn.2017.06.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498289/
https://www.ncbi.nlm.nih.gov/pubmed/28918018
http://dx.doi.org/10.1016/j.omtn.2017.06.012

Ejemplares similares