Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA

Two mechanisms dominate the clinical pipeline for oligonucleotide-based gene silencing, namely, the antisense approach that recruits RNase H to cleave target RNA and the RNAi approach that recruits the RISC complex to cleave target RNA. Multiple chemical designs can be used to elicit each pathway. W...

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Detalles Bibliográficos
Autores principales: Pendergraff, Hannah M., Krishnamurthy, Pranathi Meda, Debacker, Alexandre J., Moazami, Michael P., Sharma, Vivek K., Niitsoo, Liisa, Yu, Yong, Tan, Yen Nee, Haitchi, Hans Michael, Watts, Jonathan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498289/
https://www.ncbi.nlm.nih.gov/pubmed/28918018
http://dx.doi.org/10.1016/j.omtn.2017.06.012

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