Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion

In obesity fasting levels of both glucagon and insulin are elevated. In these subjects fasting levels of the free fatty acid palmitate are raised. We have demonstrated that palmitate enhances glucose-stimulated insulin secretion from isolated human islets via free fatty acid receptor 1 (FFAR1/GPR40)...

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Detalles Bibliográficos
Autores principales: Kristinsson, H., Sargsyan, E., Manell, H., Smith, D. M., Göpel, S. O., Bergsten, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498543/
https://www.ncbi.nlm.nih.gov/pubmed/28680093
http://dx.doi.org/10.1038/s41598-017-04730-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498543/
https://www.ncbi.nlm.nih.gov/pubmed/28680093
http://dx.doi.org/10.1038/s41598-017-04730-5

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