Virtual Screening, pharmacophore development and structure based similarity search to identify inhibitors against IdeR, a transcription factor of Mycobacterium tuberculosis

ideR, an essential gene of Mycobacterium tuberculosis, is an attractive drug target as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To the best of our knowledge, no inhibitors of IdeR are identified. We carried out virtual screening of NCI database against the...

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Detalles Bibliográficos
Autores principales: Rohilla, Akshay, Khare, Garima, Tyagi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498548/
https://www.ncbi.nlm.nih.gov/pubmed/28680150
http://dx.doi.org/10.1038/s41598-017-04748-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498548/
https://www.ncbi.nlm.nih.gov/pubmed/28680150
http://dx.doi.org/10.1038/s41598-017-04748-9

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