Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability

Tuberculosis (TB) is a global health problem that affects over 10 million people. There is an urgent need to develop novel antimicrobial therapies to combat TB. To achieve this, a thorough understanding of key validated drug targets is required. The enoyl reductase InhA, responsible for synthesis of...

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Detalles Bibliográficos
Autores principales: Shaw, Daniel J., Robb, Kirsty, Vetter, Beatrice V., Tong, Madeline, Molle, Virginie, Hunt, Neil T., Hoskisson, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498604/
https://www.ncbi.nlm.nih.gov/pubmed/28680153
http://dx.doi.org/10.1038/s41598-017-05042-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498604/
https://www.ncbi.nlm.nih.gov/pubmed/28680153
http://dx.doi.org/10.1038/s41598-017-05042-4

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