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Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability
Tuberculosis (TB) is a global health problem that affects over 10 million people. There is an urgent need to develop novel antimicrobial therapies to combat TB. To achieve this, a thorough understanding of key validated drug targets is required. The enoyl reductase InhA, responsible for synthesis of...
Autores principales: | Shaw, Daniel J., Robb, Kirsty, Vetter, Beatrice V., Tong, Madeline, Molle, Virginie, Hunt, Neil T., Hoskisson, Paul A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498604/ https://www.ncbi.nlm.nih.gov/pubmed/28680153 http://dx.doi.org/10.1038/s41598-017-05042-4 |
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