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Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet

Current efforts are directed to reducing the gut dysbiosis and inflammation produced by obesity. The purpose of this study was to investigate whether consuming nopal, a vegetable rich in dietary fibre, vitamin C, and polyphenols can reduce the metabolic consequences of obesity by modifying the gut m...

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Autores principales: Sánchez-Tapia, Mónica, Aguilar-López, Miriam, Pérez-Cruz, Claudia, Pichardo-Ontiveros, Edgar, Wang, Mei, Donovan, Sharon M., Tovar, Armando R., Torres, Nimbe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498631/
https://www.ncbi.nlm.nih.gov/pubmed/28680065
http://dx.doi.org/10.1038/s41598-017-05096-4
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author Sánchez-Tapia, Mónica
Aguilar-López, Miriam
Pérez-Cruz, Claudia
Pichardo-Ontiveros, Edgar
Wang, Mei
Donovan, Sharon M.
Tovar, Armando R.
Torres, Nimbe
author_facet Sánchez-Tapia, Mónica
Aguilar-López, Miriam
Pérez-Cruz, Claudia
Pichardo-Ontiveros, Edgar
Wang, Mei
Donovan, Sharon M.
Tovar, Armando R.
Torres, Nimbe
author_sort Sánchez-Tapia, Mónica
collection PubMed
description Current efforts are directed to reducing the gut dysbiosis and inflammation produced by obesity. The purpose of this study was to investigate whether consuming nopal, a vegetable rich in dietary fibre, vitamin C, and polyphenols can reduce the metabolic consequences of obesity by modifying the gut microbiota and preventing metabolic endotoxemia in rats fed a high fat and sucrose diet. With this aim, rats were fed a high fat diet with 5% sucrose in the drinking water (HFS) for 7 months and then were fed for 1 month with HFS + 5% nopal (HFS + N). The composition of gut microbiota was assessed by sequencing the 16S rRNA gene. Nopal modified gut microbiota and increased intestinal occludin-1 in the HFS + N group. This was associated with a decrease in metabolic endotoxemia, glucose insulinotropic peptide, glucose intolerance, lipogenesis, and metabolic inflexibility. These changes were accompanied by reduced hepatic steatosis and oxidative stress in adipose tissue and brain, and improved cognitive function, associated with an increase in B. fragilis. This study supports the use of nopal as a functional food and prebiotic for its ability to modify gut microbiota and to reduce metabolic endotoxemia and other obesity-related biochemical abnormalities.
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spelling pubmed-54986312017-07-10 Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet Sánchez-Tapia, Mónica Aguilar-López, Miriam Pérez-Cruz, Claudia Pichardo-Ontiveros, Edgar Wang, Mei Donovan, Sharon M. Tovar, Armando R. Torres, Nimbe Sci Rep Article Current efforts are directed to reducing the gut dysbiosis and inflammation produced by obesity. The purpose of this study was to investigate whether consuming nopal, a vegetable rich in dietary fibre, vitamin C, and polyphenols can reduce the metabolic consequences of obesity by modifying the gut microbiota and preventing metabolic endotoxemia in rats fed a high fat and sucrose diet. With this aim, rats were fed a high fat diet with 5% sucrose in the drinking water (HFS) for 7 months and then were fed for 1 month with HFS + 5% nopal (HFS + N). The composition of gut microbiota was assessed by sequencing the 16S rRNA gene. Nopal modified gut microbiota and increased intestinal occludin-1 in the HFS + N group. This was associated with a decrease in metabolic endotoxemia, glucose insulinotropic peptide, glucose intolerance, lipogenesis, and metabolic inflexibility. These changes were accompanied by reduced hepatic steatosis and oxidative stress in adipose tissue and brain, and improved cognitive function, associated with an increase in B. fragilis. This study supports the use of nopal as a functional food and prebiotic for its ability to modify gut microbiota and to reduce metabolic endotoxemia and other obesity-related biochemical abnormalities. Nature Publishing Group UK 2017-07-05 /pmc/articles/PMC5498631/ /pubmed/28680065 http://dx.doi.org/10.1038/s41598-017-05096-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sánchez-Tapia, Mónica
Aguilar-López, Miriam
Pérez-Cruz, Claudia
Pichardo-Ontiveros, Edgar
Wang, Mei
Donovan, Sharon M.
Tovar, Armando R.
Torres, Nimbe
Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_full Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_fullStr Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_full_unstemmed Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_short Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
title_sort nopal (opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498631/
https://www.ncbi.nlm.nih.gov/pubmed/28680065
http://dx.doi.org/10.1038/s41598-017-05096-4
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