Cargando…

Coiled-coil interactions mediate serine integrase directionality

Serine integrases are bacteriophage enzymes that carry out site-specific integration and excision of their viral genomes. The integration reaction is highly directional; recombination between the phage attachment site attP and the host attachment site attB to form the hybrid sites attL and attR is e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Kushol, Sharp, Robert, Yuan, Jimmy B., Li, Huiguang, Van Duyne, Gregory D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499577/ https://www.ncbi.nlm.nih.gov/pubmed/28549184 http://dx.doi.org/10.1093/nar/gkx474

Ejemplares similares

Requirements for catalysis in the Cre recombinase active site
por: Gibb, Bryan, et al.
Publicado: (2010)

Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif
por: Hirtreiter, Angela, et al.
Publicado: (2010)

The mechanism of ϕC31 integrase directionality: experimental analysis and computational modelling
por: Pokhilko, Alexandra, et al.
Publicado: (2016)

A motif in the C-terminal domain of ϕC31 integrase controls the directionality of recombination
por: Rowley, Paul A., et al.
Publicado: (2008)

Functional and structural characterization of the integrase from the prototype foamy virus
por: Valkov, Eugene, et al.
Publicado: (2009)

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
por: Cherepanov, Peter
Publicado: (2007)

Sequence motifs recognized by the casposon integrase of Aciduliprofundum boonei
por: Béguin, Pierre, et al.
Publicado: (2019)

In vitro initial attachment of HIV-1 integrase to viral ends: control of the DNA specific interaction by the oligomerization state
por: Lesbats, P., et al.
Publicado: (2008)

Single-molecule analysis of ϕC31 integrase-mediated site-specific recombination by tethered particle motion
por: Fan, Hsiu-Fang, et al.
Publicado: (2016)

Spermidine biases the resolution of Holliday junctions by phage λ integrase
por: Boldt, Jeffrey L., et al.
Publicado: (2007)

Cell type differences in activity of the Streptomyces bacteriophage ϕC31 integrase
por: Maucksch, Christof, et al.
Publicado: (2008)

CTnDOT integrase performs ordered homology-dependent and homology-independent strand exchanges
por: Malanowska, Karolina, et al.
Publicado: (2007)

DNA binding and synapsis by the large C-terminal domain of ϕC31 integrase
por: McEwan, Andrew R., et al.
Publicado: (2009)

Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75
por: Lapaillerie, Delphine, et al.
Publicado: (2021)

Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization
por: Tang, Xiaoli, et al.
Publicado: (2010)

Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase
por: Mauro, Eric, et al.
Publicado: (2019)

Zinc is essential for high-affinity DNA binding and recombinase activity of φC31 integrase
por: McEwan, Andrew R., et al.
Publicado: (2011)

B′-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase
por: Maertens, Goedele N.
Publicado: (2016)

Selectivity for strand-transfer over 3′-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme–DNA interactions in the active site
por: Métifiot, Mathieu, et al.
Publicado: (2016)

Role of metal ions in catalysis by HIV integrase analyzed using a quantitative PCR disintegration assay
por: Diamond, Tracy L., et al.
Publicado: (2006)

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding
por: Serrao, Erik, et al.
Publicado: (2014)

The casposon-encoded Cas1 protein from Aciduliprofundum boonei is a DNA integrase that generates target site duplications
por: Hickman, Alison B., et al.
Publicado: (2015)

DNA binding specificities of Escherichia coli Cas1–Cas2 integrase drive its recruitment at the CRISPR locus
por: Moch, Clara, et al.
Publicado: (2017)

Identification of key structural determinants of the IntI1 integron integrase that influence attC × attI1 recombination efficiency
por: Demarre, Gaëlle, et al.
Publicado: (2007)

The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation
por: Delelis, Olivier, et al.
Publicado: (2009)

A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain
por: Carayon, Kevin, et al.
Publicado: (2010)

Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts
por: Povirk, Lawrence F., et al.
Publicado: (2007)

Attachment site recognition and regulation of directionality by the serine integrases
por: Rutherford, Karen, et al.
Publicado: (2013)

Casein kinase I δ/ɛ phosphorylates topoisomerase IIα at serine-1106 and modulates DNA cleavage activity
por: Grozav, Adrian G., et al.
Publicado: (2009)

Crossover-site sequence and DNA torsional stress control strand interchanges by the Bxb1 site-specific serine recombinase
por: Keenholtz, Ross A., et al.
Publicado: (2016)

RecG interacts directly with SSB: implications for stalled replication fork regression
por: Buss, Jackson A., et al.
Publicado: (2008)

Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages
por: Olorunniji, Femi J., et al.
Publicado: (2015)

TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA
por: Kaur, Parminder, et al.
Publicado: (2021)

Adjacent single-stranded regions mediate processing of tRNA precursors by RNase E direct entry
por: Kime, Louise, et al.
Publicado: (2014)

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance
por: Aldred, Katie J., et al.
Publicado: (2013)

Protein–RNA and protein–protein interactions mediate association of human EST1A/SMG6 with telomerase
por: Redon, Sophie, et al.
Publicado: (2007)

A dual-functional priming-capping loop of rhabdoviral RNA polymerases directs terminal de novo initiation and capping intermediate formation
por: Ogino, Minako, et al.
Publicado: (2019)

Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nuclease
por: Christensen, Laura A., et al.
Publicado: (2008)

Rational evolution of Cd(2+)-specific DNAzymes with phosphorothioate modified cleavage junction and Cd(2+) sensing
por: Huang, Po-Jung Jimmy, et al.
Publicado: (2015)

Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS
por: Monti, Maria Chiara, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_idhmovoftn6m75f6l8i2ru83oo