Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state

The emergence of multi-drug resistant bacteria is limiting the effectiveness of commonly used antibiotics, which spurs a renewed interest in revisiting older and poorly studied drugs. Streptogramins A is a class of protein synthesis inhibitors that target the peptidyl transferase center (PTC) on the...

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Detalles Bibliográficos
Autores principales: Osterman, Ilya A., Khabibullina, Nelli F., Komarova, Ekaterina S., Kasatsky, Pavel, Kartsev, Victor G., Bogdanov, Alexey A., Dontsova, Olga A., Konevega, Andrey L., Sergiev, Petr V., Polikanov, Yury S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499580/
https://www.ncbi.nlm.nih.gov/pubmed/28505372
http://dx.doi.org/10.1093/nar/gkx413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499580/
https://www.ncbi.nlm.nih.gov/pubmed/28505372
http://dx.doi.org/10.1093/nar/gkx413

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