PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination

Under normal, non-stressed conditions, intracellular p53 is continually ubiquitinated by MDM2 and targeted for degradation. However, in response to severe genotoxic stress, p53 protein levels are markedly increased and apoptotic cell death is triggered. Inhibiting the ubiquitination of p53 under con...

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Detalles Bibliográficos
Autores principales: Jin, Min, Park, Seon-Joo, Kim, Seok Won, Kim, Hye Rim, Hyun, Jin Won, Lee, Jung-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499618/
https://www.ncbi.nlm.nih.gov/pubmed/28605833
http://dx.doi.org/10.4062/biomolther.2017.086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499618/
https://www.ncbi.nlm.nih.gov/pubmed/28605833
http://dx.doi.org/10.4062/biomolther.2017.086

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