Transcriptional mutagenesis reduces splicing fidelity in mammalian cells

Splicing fidelity is essential to the maintenance of cellular functions and viability, and mutations or natural variations in pre-mRNA sequences and consequent alteration of splicing have been implicated in the etiology and progression of numerous diseases. The extent to which transcriptional errors...

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Detalles Bibliográficos
Autores principales: Paredes, João A., Ezerskyte, Monika, Bottai, Matteo, Dreij, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499639/
https://www.ncbi.nlm.nih.gov/pubmed/28460122
http://dx.doi.org/10.1093/nar/gkx339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499639/
https://www.ncbi.nlm.nih.gov/pubmed/28460122
http://dx.doi.org/10.1093/nar/gkx339

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