The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters

One third of tumor suppressors are haploinsufficient transcriptional regulators, yet it remains unknown how a 50% reduction of a transcription factor is translated at the cis-regulatory level into a malignant transcriptional program. We studied CUX1, a haploinsufficient transcription factor that is...

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Detalles Bibliográficos
Autores principales: Arthur, Robert K., An, Ningfei, Khan, Saira, McNerney, Megan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499738/
https://www.ncbi.nlm.nih.gov/pubmed/28369554
http://dx.doi.org/10.1093/nar/gkx218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499738/
https://www.ncbi.nlm.nih.gov/pubmed/28369554
http://dx.doi.org/10.1093/nar/gkx218

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