Strong transcription blockage mediated by R-loop formation within a G-rich homopurine–homopyrimidine sequence localized in the vicinity of the promoter

Guanine-rich (G-rich) homopurine–homopyrimidine nucleotide sequences can block transcription with an efficiency that depends upon their orientation, composition and length, as well as the presence of negative supercoiling or breaks in the non-template DNA strand. We report that a G-rich sequence in...

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Detalles Bibliográficos
Autores principales: Belotserkovskii, Boris P., Soo Shin, Jane Hae, Hanawalt, Philip C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499740/
https://www.ncbi.nlm.nih.gov/pubmed/28498974
http://dx.doi.org/10.1093/nar/gkx403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499740/
https://www.ncbi.nlm.nih.gov/pubmed/28498974
http://dx.doi.org/10.1093/nar/gkx403

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