CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion

CDK12 (cyclin-dependent kinase 12) is a regulatory kinase with evolutionarily conserved roles in modulating transcription elongation. Recent tumor genome studies of breast and ovarian cancers highlighted recurrent CDK12 mutations, which have been shown to disrupt DNA repair in cell-based assays. In...

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Detalles Bibliográficos
Autores principales: Tien, Jerry F., Mazloomian, Alborz, Cheng, S.-W. Grace, Hughes, Christopher S., Chow, Christalle C.T., Canapi, Leanna T., Oloumi, Arusha, Trigo-Gonzalez, Genny, Bashashati, Ali, Xu, James, Chang, Vicky C.-D., Shah, Sohrab P., Aparicio, Samuel, Morin, Gregg B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499812/
https://www.ncbi.nlm.nih.gov/pubmed/28334900
http://dx.doi.org/10.1093/nar/gkx187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499812/
https://www.ncbi.nlm.nih.gov/pubmed/28334900
http://dx.doi.org/10.1093/nar/gkx187

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