Cargando…

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion

CDK12 (cyclin-dependent kinase 12) is a regulatory kinase with evolutionarily conserved roles in modulating transcription elongation. Recent tumor genome studies of breast and ovarian cancers highlighted recurrent CDK12 mutations, which have been shown to disrupt DNA repair in cell-based assays. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tien, Jerry F., Mazloomian, Alborz, Cheng, S.-W. Grace, Hughes, Christopher S., Chow, Christalle C.T., Canapi, Leanna T., Oloumi, Arusha, Trigo-Gonzalez, Genny, Bashashati, Ali, Xu, James, Chang, Vicky C.-D., Shah, Sohrab P., Aparicio, Samuel, Morin, Gregg B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499812/ https://www.ncbi.nlm.nih.gov/pubmed/28334900 http://dx.doi.org/10.1093/nar/gkx187

Ejemplares similares

Oxidative stress controls the choice of alternative last exons via a Brahma–BRCA1–CstF pathway
por: Fontana, Gabriele A., et al.
Publicado: (2017)

JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data
por: Roth, Andrew, et al.
Publicado: (2012)

Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation
por: Mazloomian, Alborz, et al.
Publicado: (2019)

The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
por: Reiter, Veronika, et al.
Publicado: (2012)

Feature-based classifiers for somatic mutation detection in tumour–normal paired sequencing data
por: Ding, Jiarui, et al.
Publicado: (2012)

Functional properties and evolutionary splicing constraints on a composite exonic regulatory element of splicing in CFTR exon 12
por: Haque, Ariful, et al.
Publicado: (2010)

An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion
por: Collins, Katherine M., et al.
Publicado: (2017)

TRAP150 activates splicing in composite terminal exons
por: Lee, Kuo-Ming, et al.
Publicado: (2014)

Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation
por: Egecioglu, Defne E., et al.
Publicado: (2012)

Splicing of internal large exons is defined by novel cis-acting sequence elements
por: Bolisetty, Mohan T., et al.
Publicado: (2012)

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A
por: Qian, Wei, et al.
Publicado: (2011)

Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF
por: Chen, Zhiqi, et al.
Publicado: (2010)

TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR
por: Fiesel, Fabienne C., et al.
Publicado: (2012)

Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position
por: Shen, Manli, et al.
Publicado: (2012)

SR protein-mediated inhibition of CFTR exon 9 inclusion: molecular characterization of the intronic splicing silencer
por: Buratti, Emanuele, et al.
Publicado: (2007)

Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members
por: Wang, Huiwen, et al.
Publicado: (2010)

Efficient internal exon recognition depends on near equal contributions from the 3′ and 5′ splice sites
por: Shepard, Peter J., et al.
Publicado: (2011)

HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing
por: Preußner, Marco, et al.
Publicado: (2012)

Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons
por: Kralovicova, Jana, et al.
Publicado: (2017)

AG-dependent 3′-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon
por: Fu, Yuan, et al.
Publicado: (2011)

The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer
por: Didiot, Marie-Cécile, et al.
Publicado: (2008)

Global control of aberrant splice-site activation by auxiliary splicing sequences: evidence for a gradient in exon and intron definition
por: Královičová, Jana, et al.
Publicado: (2007)

Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing
por: Mazloomian, Alborz, et al.
Publicado: (2015)

YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts
por: Wei, Wen-Juan, et al.
Publicado: (2012)

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2
por: Du, William W., et al.
Publicado: (2016)

The U1, U2 and U5 snRNAs crosslink to the 5′ exon during yeast pre-mRNA splicing
por: McGrail, Joanne C., et al.
Publicado: (2008)

The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway
por: Viegas, Marcelo H., et al.
Publicado: (2007)

Regulation of the Mutually Exclusive Exons 8a and 8 in the CaV1.2 Calcium Channel Transcript by Polypyrimidine Tract-binding Protein
por: Tang, Zhen Zhi, et al.
Publicado: (2011)

Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron
por: Echeverria, Gloria V., et al.
Publicado: (2014)

CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes
por: Steckelberg, Anna-Lena, et al.
Publicado: (2015)

Reduced splicing efficiency induced by synonymous substitutions may generate a substrate for natural selection of new splicing isoforms: the case of CFTR exon 12
por: Raponi, Michela, et al.
Publicado: (2007)

Self-splicing of a group IIC intron: 5′ exon recognition and alternative 5′ splicing events implicate the stem–loop motif of a transcriptional terminator
por: Toor, Navtej, et al.
Publicado: (2006)

Tissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1γ gene
por: Fukumura, Kazuhiro, et al.
Publicado: (2007)

Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3′ splice-site organization and activity of U2AF-related proteins
por: Kralovicova, Jana, et al.
Publicado: (2015)

Structural disruption of exonic stem–loops immediately upstream of the intron regulates mammalian splicing
por: Saha, Kaushik, et al.
Publicado: (2020)

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer
por: Ha, Gavin, et al.
Publicado: (2012)

Splice-shifting oligonucleotide (SSO) mediated blocking of an exonic splicing enhancer (ESE) created by the prevalent c.903+469T>C MTRR mutation corrects splicing and restores enzyme activity in patient cells
por: Palhais, Bruno, et al.
Publicado: (2015)

CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex
por: Gerbracht, Jennifer V, et al.
Publicado: (2020)

The RNA binding protein Quaking represses splicing of the Fibronectin EDA exon and downregulates the interferon response
por: Liao, Kuo-Chieh, et al.
Publicado: (2021)

Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia
por: de Oliveira Freitas Machado, Camila, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_uc06gj6fi1pt09tmrjq4ug9lih