SAMHD1 protects cancer cells from various nucleoside-based antimetabolites

Recently, we demonstrated that sterile α motif and HD domain containing protein 1 (SAMHD1) is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity of cytarabine (ara-C), the most important drug in AML treatment. Ara-C is intracellularly converted by the canonical dNTP synthe...

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Detalles Bibliográficos
Autores principales: Herold, Nikolas, Rudd, Sean G., Sanjiv, Kumar, Kutzner, Juliane, Bladh, Julia, Paulin, Cynthia B. J., Helleday, Thomas, Henter, Jan-Inge, Schaller, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499833/
https://www.ncbi.nlm.nih.gov/pubmed/28436707
http://dx.doi.org/10.1080/15384101.2017.1314407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499833/
https://www.ncbi.nlm.nih.gov/pubmed/28436707
http://dx.doi.org/10.1080/15384101.2017.1314407

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