Modeling bias and variation in the stochastic processes of small RNA sequencing

The use of RNA-seq as the preferred method for the discovery and validation of small RNA biomarkers has been hindered by high quantitative variability and biased sequence counts. In this paper we develop a statistical model for sequence counts that accounts for ligase bias and stochastic variation i...

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Detalles Bibliográficos
Autores principales: Argyropoulos, Christos, Etheridge, Alton, Sakhanenko, Nikita, Galas, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499834/
https://www.ncbi.nlm.nih.gov/pubmed/28369495
http://dx.doi.org/10.1093/nar/gkx199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499834/
https://www.ncbi.nlm.nih.gov/pubmed/28369495
http://dx.doi.org/10.1093/nar/gkx199

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