Interstrand cross-links arising from strand breaks at true abasic sites in duplex DNA

Interstrand cross-links are exceptionally bioactive DNA lesions. Endogenous generation of interstrand cross-links in genomic DNA may contribute to aging, neurodegeneration, and cancer. Abasic (Ap) sites are common lesions in genomic DNA that readily undergo spontaneous and amine-catalyzed strand cle...

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Detalles Bibliográficos
Autores principales: Yang, Zhiyu, Price, Nathan E., Johnson, Kevin M., Wang, Yinsheng, Gates, Kent S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499897/
https://www.ncbi.nlm.nih.gov/pubmed/28531327
http://dx.doi.org/10.1093/nar/gkx394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499897/
https://www.ncbi.nlm.nih.gov/pubmed/28531327
http://dx.doi.org/10.1093/nar/gkx394

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