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Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling
Lithium is widely used as a treatment for Bipolar Disorder although the molecular mechanisms that underlie its therapeutic effects are under debate. In this study, we show brain-derived neurotrophic factor (BDNF) is required for the antimanic-like effects of lithium but not the antidepressant-like e...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499943/ https://www.ncbi.nlm.nih.gov/pubmed/28621662 http://dx.doi.org/10.7554/eLife.25480 |