Effect of APOE ε4 allele on survival and fertility in an adverse environment

BACKGROUND: The apolipoprotein-ε4 allele (APOE-ε4) is strongly associated with detrimental outcomes in affluent populations including atherosclerotic disease, Alzheimer’s disease, and reduced lifespan. Despite these detrimental outcomes, population frequencies of APOE-ε4 are high. We hypothesize tha...

Descripción completa

Detalles Bibliográficos
Autores principales: van Exel, Eric, Koopman, Jacob J. E., van Bodegom, David, Meij, Johannes J., de Knijff, Peter, Ziem, Juventus B., Finch, Caleb E., Westendorp, Rudi G. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500260/
https://www.ncbi.nlm.nih.gov/pubmed/28683096
http://dx.doi.org/10.1371/journal.pone.0179497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500260/
https://www.ncbi.nlm.nih.gov/pubmed/28683096
http://dx.doi.org/10.1371/journal.pone.0179497

Ejemplares similares