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Effect of APOE ε4 allele on survival and fertility in an adverse environment

BACKGROUND: The apolipoprotein-ε4 allele (APOE-ε4) is strongly associated with detrimental outcomes in affluent populations including atherosclerotic disease, Alzheimer’s disease, and reduced lifespan. Despite these detrimental outcomes, population frequencies of APOE-ε4 are high. We hypothesize tha...

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Detalles Bibliográficos
Autores principales:	van Exel, Eric, Koopman, Jacob J. E., van Bodegom, David, Meij, Johannes J., de Knijff, Peter, Ziem, Juventus B., Finch, Caleb E., Westendorp, Rudi G. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500260/ https://www.ncbi.nlm.nih.gov/pubmed/28683096 http://dx.doi.org/10.1371/journal.pone.0179497

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