Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

MODY1 is a maturity-onset monogenic diabetes, caused by heterozygous mutations of the HNF4A gene. To date the cellular and molecular mechanisms leading to disease onset remain largely unknown. In this study, we demonstrate that insulin-positive cells can be generated in vitro from human induced plur...

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Detalles Bibliográficos
Autores principales: Vethe, Heidrun, Bjørlykke, Yngvild, Ghila, Luiza M., Paulo, Joao A., Scholz, Hanne, Gygi, Steven P., Chera, Simona, Ræder, Helge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500592/
https://www.ncbi.nlm.nih.gov/pubmed/28684784
http://dx.doi.org/10.1038/s41598-017-04979-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500592/
https://www.ncbi.nlm.nih.gov/pubmed/28684784
http://dx.doi.org/10.1038/s41598-017-04979-w

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