Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function

Angiogenesis and blood–brain barrier formation are required for normal central nervous system (CNS) function. Both processes are controlled by Wnt or Norrin (NDP) ligands, Frizzled (FZD) receptors, and β-catenin-dependent signalling in vascular endothelial cells. In the retina, FZD4 and the ligand N...

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Detalles Bibliográficos
Autores principales: Zhang, Chi, Lai, Maria B., Khandan, Lavan, Lee, Lindsey A., Chen, Zhe, Junge, Harald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500887/
https://www.ncbi.nlm.nih.gov/pubmed/28675177
http://dx.doi.org/10.1038/ncomms16050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500887/
https://www.ncbi.nlm.nih.gov/pubmed/28675177
http://dx.doi.org/10.1038/ncomms16050

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