Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

BACKGROUND: Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have...

Descripción completa

Detalles Bibliográficos
Autores principales: López Rodríguez, Maykel, Kaminska, Dorota, Lappalainen, Kati, Pihlajamäki, Jussi, Kaikkonen, Minna U., Laakso, Markku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501007/
https://www.ncbi.nlm.nih.gov/pubmed/28683826
http://dx.doi.org/10.1186/s13073-017-0453-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501007/
https://www.ncbi.nlm.nih.gov/pubmed/28683826
http://dx.doi.org/10.1186/s13073-017-0453-x

Ejemplares similares