Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

BACKGROUND: Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have...

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Detalles Bibliográficos
Autores principales: López Rodríguez, Maykel, Kaminska, Dorota, Lappalainen, Kati, Pihlajamäki, Jussi, Kaikkonen, Minna U., Laakso, Markku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501007/
https://www.ncbi.nlm.nih.gov/pubmed/28683826
http://dx.doi.org/10.1186/s13073-017-0453-x

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