Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition

Chronic oxidative injury produced by airway disease triggers TGFβ-mediated epigenetic reprogramming known as the epithelial-mesenchymal transition (EMT). We observe that EMT silences protective mucosal interferon (IFN)-I/-III production associated with enhanced rhinovirus (RV) and respiratory syncyt...

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Detalles Bibliográficos
Autores principales: Yang, Jun, Tian, Bing, Sun, Hong, Garofalo, Roberto P., Brasier, Allan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501188/
https://www.ncbi.nlm.nih.gov/pubmed/28581456
http://dx.doi.org/10.1038/nmicrobiol.2017.86

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501188/
https://www.ncbi.nlm.nih.gov/pubmed/28581456
http://dx.doi.org/10.1038/nmicrobiol.2017.86

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