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Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition

Chronic oxidative injury produced by airway disease triggers TGFβ-mediated epigenetic reprogramming known as the epithelial-mesenchymal transition (EMT). We observe that EMT silences protective mucosal interferon (IFN)-I/-III production associated with enhanced rhinovirus (RV) and respiratory syncyt...

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Detalles Bibliográficos
Autores principales:	Yang, Jun, Tian, Bing, Sun, Hong, Garofalo, Roberto P., Brasier, Allan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501188/ https://www.ncbi.nlm.nih.gov/pubmed/28581456 http://dx.doi.org/10.1038/nmicrobiol.2017.86

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