Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children

BACKGROUND: There are no therapies shown to improve outcome after severe traumatic brain injury (TBI) in humans, a leading cause of morbidity and mortality. We sought to verify brain exposure of the systemically administered antioxidant N-acetylcysteine (NAC) and the synergistic adjuvant probenecid,...

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Detalles Bibliográficos
Autores principales: Clark, Robert S. B., Empey, Philip E., Bayır, Hülya, Rosario, Bedda L., Poloyac, Samuel M., Kochanek, Patrick M., Nolin, Thomas D., Au, Alicia K., Horvat, Christopher M., Wisniewski, Stephen R., Bell, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501440/
https://www.ncbi.nlm.nih.gov/pubmed/28686657
http://dx.doi.org/10.1371/journal.pone.0180280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501440/
https://www.ncbi.nlm.nih.gov/pubmed/28686657
http://dx.doi.org/10.1371/journal.pone.0180280

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