A hypoxia response element in the Vegfa promoter is required for basal Vegfa expression in skin and for optimal granulation tissue formation during wound healing in mice

Hypoxia in skin wounds is thought to contribute to healing through the induction of hypoxia inducible factor-1 (HIF-1). Although HIF-1 can regulate the expression of vascular endothelial growth factor A (Vegfa), whether hypoxia and HIF-1 are required to induce Vegfa expression in the context of woun...

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Detalles Bibliográficos
Autores principales: Ciarlillo, Domenic, Celeste, Christophe, Carmeliet, Peter, Boerboom, Derek, Theoret, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501577/
https://www.ncbi.nlm.nih.gov/pubmed/28686658
http://dx.doi.org/10.1371/journal.pone.0180586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501577/
https://www.ncbi.nlm.nih.gov/pubmed/28686658
http://dx.doi.org/10.1371/journal.pone.0180586

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