Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria

Vancomycin is known to bind to Zn(II) and can induce a zinc starvation response in bacteria. Here we identify a novel polymerization of vancomycin dimers by structural analysis of vancomycin-Zn(II) crystals and fibre X-ray diffraction. Bioassays indicate that this structure is associated with an inc...

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Detalles Bibliográficos
Autores principales: Zarkan, Ashraf, Macklyne, Heather-Rose, Chirgadze, Dimitri Y., Bond, Andrew D., Hesketh, Andrew R., Hong, Hee-Jeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501778/
https://www.ncbi.nlm.nih.gov/pubmed/28687742
http://dx.doi.org/10.1038/s41598-017-04868-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501778/
https://www.ncbi.nlm.nih.gov/pubmed/28687742
http://dx.doi.org/10.1038/s41598-017-04868-2

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