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Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria
Vancomycin is known to bind to Zn(II) and can induce a zinc starvation response in bacteria. Here we identify a novel polymerization of vancomycin dimers by structural analysis of vancomycin-Zn(II) crystals and fibre X-ray diffraction. Bioassays indicate that this structure is associated with an inc...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501778/ https://www.ncbi.nlm.nih.gov/pubmed/28687742 http://dx.doi.org/10.1038/s41598-017-04868-2 |