P2X7 receptor antagonism modulates IL-1β and MMP9 in human atherosclerotic vessels

In atherosclerosis, matrix metallopeptidases (MMPs) contribute to plaque rupture through weakening of the fibrous cap. Pleiotropic P2X purinoceptor 7 (P2X7), expressed in the carotid plaque (PL), is involved in interleukin 1 beta (IL-1β) release that may influence MMP9 generation, thus their possibl...

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Detalles Bibliográficos
Autores principales: Lombardi, Maria, Mantione, Maria Elena, Baccellieri, Domenico, Ferrara, David, Castellano, Renata, Chiesa, Roberto, Alfieri, Ottavio, Foglieni, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501842/
https://www.ncbi.nlm.nih.gov/pubmed/28687781
http://dx.doi.org/10.1038/s41598-017-05137-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501842/
https://www.ncbi.nlm.nih.gov/pubmed/28687781
http://dx.doi.org/10.1038/s41598-017-05137-y

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